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Blood Purification

Blood purification refers to medical method that can help to treat illness by purifying blood through removing harmful substances out of the body with advanced device. There are different types of blood purification technics in medicine. Although they are all used to clear wastes out of the body and purify blood, they have different treatment effects. In medicine, for kidney failure patients, hemodialysis, plasma exchange, immune adsorption, hemoperfusion, hemofiltration and hemodiafiltration are the most commonly used blood purification method and now let’s have a general understanding about them.


Hemodialysis is also commonly called dialysis and as of now it is the most commonly used renal replacement treatment for kidney failure patients. Compared with other blood purification methods, hemodialysis shows special treatment effects in removing small molecular substances like creatinine and urea nitrogen. Plasma exchange:

Plasma exchange not only helps to remove micromolecular substances, but also macromolecular substances and middle molecular substances, so it works more effectively than other types of blood purification method. Besides, as it is especially effective in removing soluble immune complexes and certain antibodies in blood, plasma exchange is highly recommended for patients with autoimmune kidney disease like IgA Nephropathy, Lupus Nephritis and Purpura Nephritis and so on. Usually, plasma exchange is used together with immunosuppressive agents, as it only helps to clear immune complexes and antibodies away from blood and can not stop the further formation of new immune complexes and antibodies.

Immune absorption:

Immune absorption works through absorbing agents which can selectively adsorb certain pathogenic factors in blood, so as to achieve the purpose of cleaning blood. At present, immune absorption mainly focuses on removing low density lipoprotein and autoantibody, so it is also commonly used by patients with Crescentic Glomerulonephritis, IgA Nephropathy and Purpura Nephritis.


Hemoperfusion is another medical process used to purify blood. It can help to remove creatinine, uric acid, medium molecular substance, phenols, organic acid and medicines in blood, but it can not successfully clear urea nitrogen and phosphate, fluid and electrolyte. Therefore, for uremia patients, the usage of hemoperfusion is always accompanied with hemodialysis.


hemofiltration is a renal replacement therapy for kidney failure patients. Compared with hemodialysis, hemofiltration shows better effects in removing excess fluid, macromolecular substances and middle-molecular substances, but meanwhile, it can also clear micromolecular substances away from blood. Therefore, for kidney failure patients who are not allowed to do hemodialysis, they can try hemofiltration.


Hemodiafiltration is the combination of hemodialysis and hemofiltration. Hemodialysis is the most commonly used renal replacement method for kidney failure patients, but as it fails to remove middle-molecular substances and also induces the formation of new toxins, long-term usage of hemodialysis will decrease patients’ life quality and increase their mortality rate. However, patients with hemodiafiltration usually have no these worries.

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